Abstract

EVALUATION OF ANTIULCER ACTIVITY OF HYDRO-ALCOHOLIC EXTRACT OF SEEDS OF PASPALUM SCROBICULATUM LINN. (POACEAE) IN PYLORUS LIGATED WISTAR ALBINO RATS

Rajesh C.* and Suku J.

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Abstract

Objective: The purpose of this research work is to determine the ulcer protective activity of hydroalcoholic extraction of seeds of Paspalum scrobiculatum Linn in pylorus ligated Wistar albino rats. Materials and Methods: The ulcer protective effects of Paspalum scrobiculatum was studied by using pylorus ligation modal in Wistar albino rats. Wistar albino rats of either sex were divided into four groups. The control group received 0.1 mg/ml of CMC, the reference group receive omeprazole (20 mg/kg) and the test group received 200 mg/kg and 400 mg/kg of hydroalcoholic extract of Paspalum scrobiculatum by oral route. The parameters measured for antiulcer activity were gastric volume, pH, free acidity, total acidity, ulcer index and percentage protection. Results: In pyloric ligation model; the gastric volume, total and free acidity was significantly decreased at p

Keywords: Paspalum scrobiculatum; antiulcer; pylorus ligation.