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Abstract

SYNTHEIS, CHARACTERIZATION AND EVALUATION OF SEMISYNTHETIC DERIVATIVES OF LAWSONE

Shaheen Shaik* and Sreeja Vasa

Abstract

Quinones are widely distributed in nature, and several of their synthetic and natural products are very important in many diverse areas of chemistry and biochemistry. They play a fundamental role in several living cells as electron carriers in the respiratory chain, as well as in blood coagulation and carboxylation of glutamates. Due to the intimate relationship between quinones and the biochemical processes of cells, these compounds have been extensively explored in the synthesis 2 of several bioactive compounds with antitumor,[3–5] molluscicidal,[6,7] antiparasitic,[8–10] leishmanicidal,[11] antiinflammatory,[12] antifungal,[13] antimicrobial[14] and trypanocidal[15–17] activities. In the present work we have synthesised semisynthetic derivatives of lawsone 2(a-d) by Mannich base reaction. Four derivatives of Lawson were synthesized. All the compounds synthesized were obtained in good yields. Purity of compounds was confirmed by TLC and melting points and compounds were characterized by preliminary laboratory techniques like chemical tests, melting point, Rf. The synthesized compounds were screened for wound healing activity

Keywords: Quinones, Lawson, Wound healing activity, Mannich base reaction.


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