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Abstract

FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL FILMS OF ITRACONAZOLE FOR ORAL CANDIDIASIS

Fayeja S. Rajebhai*, Dr. Vishnu M. Patel, Dr. Maulik R. Mehta, Dr. Anand K. Patel

Abstract

The present investigation was intended to formulate and evaluate of mucoadhesive buccal films of Itraconazole for oral candidiasis for local therapy and improving short residence time at the site of application. Buccal film of Itraconazole was formulated by using solvent casting method. The selection of polymers were done from HPMC K 100M, Chitosan and Glycerine as plastisizer. Lactic acid was used as solvent for filmcasting. 32 factorial design was applied using X1 (Chitosan) polymer and X2 (HPMC K100M) at -1 to +1 level, for selection of optimized batch. All the parameters were found satisfactory in Chitosan with HPMC K100M batch (F4) was the most satisfactory batch as compared to other batches. The drug content, mucoadhesive strength, drug release, surface pH of developed formulation were found to be satisfactory and also showing that there were no significant changes in drug content, surface pH and drug release after performing short term stability for 1 month.

Keywords: Itraconazole, Chitosan, HPMC K100M, lactic acid.


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