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Abstract

ONE-POT SYNTHESIS OF 7, 7-DIMETHYL-4-PHENYL-2-THIOXO-2, 3, 4, 6, 7, 8- HEXAHYDRO-1H-QUINAZOLIN-5-ONES BY EMPLOYING KIO5 AS CATALYST

B. Anuradha, B. Sandhyarani, Anjali, B. Priynk and Dr. S. Srinivas Rao*

Abstract

A simple and an efficient work for the synthesis a novel series of derivatives of 7, 7-dimethyl-4-phenyl-2-thioxo-2, 3, 4, 6, 7, 8- hexahydro-1H-quinazolin-5-azone by a one-pot multicomponent cyclocondensation of dimedone and substituted aromatic aldehydes with thiourea in the presence of oxidative catalyst KIO5 in ethanol. This catalyst has beneficial features for the reaction response such as the shortest reaction time, excellent product yields, simple work-up procedure and purification of products by non-chromatographic methods. The newly obtained derivatives can be confirmed by advanced spectroscopic data such as FTIR, 1HNMR, 13CNMR and LCMS and the structural determination of the desired compounds were determined by elemental analysis.

Keywords: Dimedone, substitutedaromaticaldehydes, 7, 7-Dimethyl-4-phenyl-2-thioxo- 1, 2, 3, 4, 6, 7, 8-hexahydro-1H-quinazolin-5-ones, KIO5.


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