Abstract

FAST RATE OF CATALYST PROMOTED BY BIOACTIVE SYNTHESIS OF 2, 4, 5-TRIPHENYL IMIDAZOLE DERIVATIVES EMPLOYING METHANE SULPHONIC ACID.

M. SVS Lahari, D. Sankarao, S. Shyam, Ch. Syamala and Dr. N. Krishnarao*

Abstract

A simple, highly versatile and an efficient synthesis of 2, 4, 5- trisubstituted imidazole that was obtained by three component cyclocondensation of benzil, substituted aromatic aldehydes and ammonium acetate in solvent free condition using methane sulphonic acid acts as catalyst and solvent .The main advantages of this process are cost effectiveness of catalyst, easy work-up and purification of products by non-chromatographic methods, excellent yields and very low reaction time. One pot multicomponent reactions are very important an outstanding status in organic synthesis and medicinal chemistry for their high degree of atom economy and application in the diversity-oriented convergent conventional synthesis of complex organic molecules from simple and readily available substrates in a single vessel. The newly obtained derivatives were confirmed by advanced spectroscopic data such as FTIR, 1HNMR, 13CNMR and LCMS and the structural determination of the desired compounds were determined by elemental analysis.

Keywords: 2,4,5 -Triarylimidazole, benzil, substituted aromatic aldehydes, Ammonium acetate, Methane sulphonic acid.