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Abstract

IN VITRO ANTIDERMATOPHYTIC ACTIVITY OF ALLIUM SATIVUM L, NICOTINA TABACUM AND CADE OIL AGAINST TRICHOPHYTON RUBRUM

A. Aiboud*, A. Moussaif, N. El Abbadi, A. Ettabia, A. El hessni, A. Ouichou, M. Chakit and A. Mesfioui

Abstract

Onychomycosis is a disease that affects mainly the nails of the feet. Itis caused by different fungi especially dermatophytes whoseTrichophyton rubrum is the main cause in 80% of cases. The purposeof our study is to test the antifungal activity in vitro of differentextracts of Allium sativum L, Nicotina tabacum and Oil of Cadeusually used in traditional medicine for the treatment of skin disease inMorocco. The Minimum Inhibitory Concentration (MIC) wasdetermined using a broth microdilution method and determinedspectrophotometrically at 530 nm. T.rubrum has shown sensitivityagainst the various extracts of Allium sativum L, Nicotina tabacum andCade Oil. The Nicotina tabacum extracts have shown the best inhibitoreffect whose MICs were 0.1 μg / ml for hexanilic and chloroformicextract and 2μg/ml for the ethyl acetate extract followed by Allium sativum L whose theMICs were 10 μg / ml for the chloroformic extract and 100 μg / ml for hexanilic and ethylacetate extracts. For the Cade Oil the MICs were 100 μg / ml for liquid phase washed withhexane and the liquid phase washed with water while the MIC was 40 μg / ml for the extractof water washing. Nicotina tabacum has shown the best antifungal activity against T.rubrumfollowed by Allium sativum L and Cade Oil also. The chloroformic extract was the mostactive in comparison with hexane and ethyl acetate extracts.

Keywords: Dermatophytes; Trichophyton rubrum ; Allium sativum L; Nicotina tabacum; Cade Oil; Minimal Inhibitory Concentration.


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