Abstract

HEPATOPROTECTIVE ACTIVITY OF MULAKA (RAPHANUS SATIVUS LINN.) IN WISTAR ALBINO RATS

Sriwidya Bharati* and Swapna Bhat

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Abstract

Hepatoprotective effect of shushka mulaka churna(SMC) was investigated against paracetamol induced hepatotoxicity in wistar albino rats. It was compared with silymarin, a standard hepatoprotective reference drug. The administration of paracetamol resulted in elevated levels of liver marker enzymes and damage to hepatic cells. It was reversed by treatment with the test drug shushka mulaka churna (SMC) as observed in Therapeutically Effective Dosage (TED) group. The histopathological finding of SMC in TED*2 group shows damage to hepatic cells. The experimental study revealed that the test drug shushka mulaka churna possesses hepatoprotective activity in therapeutically effective dosage, but can cause detrimental changes to hepatocytes when given in double dosage.

Keywords: Hepatoprotective, Mulaka, Raphanus sativus Linn.