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Abstract

DESIGN AND FABRICATION OF MODERN TASTE- MASKED MEDICATED CHOCOLATES FOR AN ESTABLISHED PROTON PUMP INHIBITOR LANSOPRAZOLE FOR PAEDIATRIC DOSAGE FORM

Kruthika K. Kalmath, Shwetha S. Kamath K.*, Shashank Nayak N., Deepika D.S., Thimmasetty J.

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Abstract

Medicated chocolates plays vital role in order to grab the attention of paediatric patients. The purpose of the present work was to design a chocolate containing Lansoprazole for paediatric use to hide the bitter taste of the medication. The lansoprazole granules were prepared and evaluated for its preformulation studies. In addition, four different formulations were prepared by incorporating lansoprazole granules (equivalent to 15 mg dose of drug) with different methodology. However, formulated dosage forms were evaluated for their physical appearance, weight variation, thickness, physical stability, melting point, drug excipient interaction using differential scanning calorimetry (DSC), Fourier transform infra red spectroscopy (FTIR). The results indicates the failure of first three formulations (F1, F2, F3) to get satisfactory appearance, taste, odour and melting efficiancy. On the other hand, formulation F4 gave good results with all the evaluation parameters. So, F4 formulation was been considered as the best formulation among all the four formulations. The work's goal has been satisfactorily met by masking the unpleasant taste of Lansoprazole by making an attractive chocolate dosage form for the paediatric class.

Keywords: Lansoprazole, Medicated chocolate, Differential Scanning Calorimetry, Fourier transform infra-red spectroscopy, preformulation studies.


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