Abstract

CHITOSAN NANOPARTICLES STABILIZED BY POLOXAMER FOR CONTROLLING RIVAROXABAN RELEASE AND ENHANCING BIOAVAILABILITY: IN VITRO EVALUATION

Mohd Jalaluddin*, Ravindra Chourasiya and Mohd. Shafi Dar

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Abstract

Objective: The aim of the present study is the poloxamer stabilized chitosan nanoparticle for control release and bioavilibility enhancement of rivaroxaban. Materials and Methods: The FTIR spectra was used to identify the active fictional group in the compound. Box-Behken design (BBD) was utilized in this study to correlate dependent and independent variables. The studied variables in this work were initial drug load (X1), poloxamer percentage (X2), homogenization speed (X3). The dependent variables were particle size (Y1), entrapment efficiency (Y2). The levels of the factors were selected according to preliminary studies carried out before implementing the experimental design. In vitro release of RB from the prepared nanoparticles was conducted using USP dissolution apparatus II. Results: FT-IR results of chitosan showed the characteristic peaks for chitosan was observed at 3448cm-1 (NH stretching), 2925 cm-1 (OH stretching) &2345 cm-1 (C-H stretching), 1638 cm-1 (N-H bending primary Amine), 1405 (Cyclic ether stretching), 1075 cm-1 (C-O stretching of primary Alcohol). According to the given results, all formulations have drug release percent between 75.66 - 98.16%, at 12 hrs of time interval. All selected formulations showed the significant drug release. The highest drug release 98.16% was observed in formulation F7 as compared to the other formulations. Conclusion: These findings may contribute to the successful development of new pharmaceutical formulation F7.

Keywords: Chitosan, bioavilibility, Nanoparticles, Poloxamer, Rivaroxaban.