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Abstract

ASSESSMENT OF HEMOSTATIC EFFECTS OF OXYTOCIN AND MISOPROSTOL IN MICE

Kpahe Ziéhi Fidèle*, Atto Virginie and Konan Brou André

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Abstract

Oxytocin and Misoprostol are uterotonic drugs, used to prevent postpartum hemorrhage. This work was undertaken to evaluate the effects of oxytocin and misoprostol on blood coagulation, to demonstrate their ability to stop bleeding. Twenty four (24) mice of both sexes were used to determine the bleeding time. Split into four groups of six animals, mice were treated intramuscularly. The control group received saline solution (NaCl 0.9 %) while the Groups II and III were treated with Oxytocin (20 mg/kg) and misoprostol (20 mg/kg) respectively. Pytomenandione (20 mg/kg) used as a reference drug was administered to the last group. After a period of 20 minutes, bleeding time was measured by tail hemorrhage model. Activated partial thromboplastin time and prothrombin time were determined by a coagulometer. Misoprostol, oxytocin and phytomenandione shortened the bleeding time from 270 ± 60s to 90±5s, from 270 ± 60 s to 195±75s, and from 270 ± 60 s to 165±75 s respectively. The effects of misoprostol were significant (p˂0.01). Misoprostol, oxytocin and phytomenandione reduced, in a concentration dependent manner, activated partial thromboplastin time. At the unique concentration of 1 mg/ml, these drugs shortened significantly activated partial thromboplatin time (p˂0.1). Misoprostol and oxytocin possess hemostatic effects and could reduce bleedings in the management of postpartum hemorrhage.

Keywords: Bleeding disorders, Misoprostol, Oxytocin, Postpartum hemorrhage.


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