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Abstract

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF ASCORBIC ACID

Vaidehi R. Bodkhe* and Seema A. Gosavi

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Abstract

The development and validation of analytical methods is an integral aspect of drug discovery and drug substance development in pharmaceuticals. Analytical technique creation and validation are two tasks that are intertwined in the research and development of new therapeutic products, as well as their combination and pharmaceutical quality control. Analytical technique is a procedure for determining drug content, contaminants, and degraded products, and validation establishes that the method is correct and may be used in quality control. As new medications emerge on a daily basis, the demand for analytical technique development grows, as conventional methods for these compounds are not available in pharmacopoeias. The development of a novel analytical method aids in the enhancement of analysis accuracy, precision, cost, and time consumption. This review article emphasises on literature findings of ascorbic acid method development and validation, which will aid in the development of new methods for determining ascorbic acid in bulk and medicinal dose forms.

Keywords: Ascorbic Acid, method development, HPLC, UV, HPTLC, validation.


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