Abstract

REVIEW ON SUPERDISINTEGRANTS

Prashant Giri*, Prajakta Shinde, Anuja Sawant, Varad Kale and Abhishek Gosavi

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Abstract

Fast dissolving tablets are an emerging trend in novel drug delivery system and have increasing demand during the last few decades. Superdisintegrants are used in orally disintegrating tablet to improve the disintegration and efficacy of solid dosage forms. This is achieved by decreasing the disintegration time which in turn enhance drug dissolution rate. Disintegrates are substances which are used in formulations to promote the breakdown of the tablet (and capsule “slugs') into smaller fragments in an aqueous environment thereby increasing the available surface area and promoting a rapid release of the drug substance. Natural superdisintegrants remain an attractive role in orally disintegrating tablet because they are natural products of plants, readily available, inexpensive, biocompatible and capable of multitude of chemical modification. In recent years, some newer substances have been developed known as Superdisintegrants. Natural superdisintegrants are obtained from the natural origin and having a numbers of advantages like they are cost efficacious, nontoxic, biodegradable, ecofriendly, devoid of any side effect, renewable and also provide nutritional supplement. It is proved from variuos studies that natural polymers are more effective and safe than the synthetic polymers. The aim of the present article is to study the natural and synthetic polymers utilized and their action in fast dissolving tablet.

Keywords: Fast dissolving tablet, Disintegrants, Natural superdisintegrants, Synthetic superdisintegrants, Biodegradable, Non-toxic.