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Abstract

EVALUATION OF EXPRESSION AND DISTRIBUTION OF FIBRONECTIN ON THE ROOT SURFACE OF TEETH IN CHRONIC AND AGGRESSIVE PERIODONTITIS: AN IMMUNOHISTOCHEMICAL STUDY

*Dr. Savita S., Dr. Ambica, Dr. G. Poojitha Reddy

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Abstract

Background and Objectives: Periodontal disease is an inflammatory process which may result in damage and loss of tooth-supporting tissues, including periodontal ligament, cementum and bone. Significant evidence supports a strong correlation between periodontitis and diseased or altered cementum. Cementum contributes to the process of periodontal regeneration. The extracellular matrix (ECM) of cementum is a multicomponent three-dimensional structure composed of collagens, fibronectin, elastin, other non-collagenous proteins, and proteoglycans. Fibronectin is a dimeric glycoprotein found on the surface of cells, plasma, extracellular matrix and in the basement membrane. Fibronectin plays significant role in promoting the attachment of cells to one another, and to extracellular substrates. The present study aimed quanlitatively to analyze fibronectin on the root surface of extracted teeth of healthy, chronic and aggressive periodontitis patients. Materials and Methods: The study consisted of 45 extracted human teeth, 15 healthy teeth extracted for orthodontic purpose, 15 teeth affected by chronic periodontitis, and 15 aggressive periodontitis teeth with poor periodontal prognosis indicated for extraction were collected from patients, to analyze fibronectin on root surface using Immunohistochemistry technique. Periodontal evaluation included pocket probing depth, clinical attachment level and tooth mobility. Immediately after extraction, teeth were fixed in 2% paraformaldehyde. Following demineralization with EDTA, longitudinal sections of tissue were made on saline coated slides and Immunohistochemical staining against fibronectin was done and analyzed. Results: The expression of Fibronectin on the root surface of chronic and aggressive periodontitis patients showed statistically significant difference (p

Keywords: Fibronectin, Chronic Periodontitis, Aggressive Periodontitis.


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