Abstract

A STUDY OF ETHANOLIC EXTRACT OF ANNONA SQUAMOSA LEAVES ON BLOOD GLUCOSE LEVELS AND BODY WEIGHT CHANGES IN DIABETIC RATS

Mohan Pakala, Sandhya Priya Parthasaradhi* and Rupa Devi Mopati

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Abstract

Diabetes is one of the most common chronic diseases. Now a days, so many people have been suffering with Diabetes mellitus. It is a metabolic disorder in which glucose levels are increased in the blood. This hyperglycemic condition effects the metabolic activities in the body and cause symptoms like extreme thirst, frequent urination, blurred vision, Fatigue, Weight loss, Poor wound healing, Dry or itchy skin, Impotence, Recurrent Infections etc. In Diabetes, the oxidative stress enhances the free radical formation which leads to chronic disorders in which glucose levels will be enhanced and body weight changes will occur. In our study, we have used the ethanolic extract of Annona squamosa l eaves on diabetic rat, these leaves decreased the blood glucose levels nearer to the referral drug.

Keywords: Diabetes mellitus, Free radicals, Oxidative stress, Annona squamosa, Streptozotocin. Glibenclaimade.