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Abstract

IN SILICO STUDY: THE BLUE BUTTERFLY PEA FLOWER (CLITORIA TERNATEA L.) COMPOUND HAS POTENTIAL FOR HERBAL MEDICINE FOR COVID-19

Safira Yulita Fazadini and Achmad Yzzuddin*

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Abstract

The number of outbreaks of COVID-19 cases in the world continues to grow until April 2022. Certain drugs that are officially approved for the treatment of COVID-19 are still under development. Several vaccines have been circulating, but the distribution is not complete. Research on the use of herbs for the treatment of COVID-19 is also ongoing. In Asia, herbs as a treatment have been widely used such as Blue Butterfly Pea Flower (Clitoria ternatea L.) is a plant that is commonly found in Asia with many benefits such as anti-bacterial, antiviral, and so on but has not been widely studied. Blue Butterfly Pea Flower (Clitoria ternatea L.) is a plant that is commonly found in Asia. This study aimed to determine 44 compound contained in the Blue Butterfly Pea Flower, which have the potential as the Main Protease Inhibitor of Sars-Cov-2 based on their Druglikeness, Toxicity Properties and In Silico Study. This research method From 44 compound, has seven compounds have met the druglikeness and toxicity properties requirements then proceed with activity analysis using In Silico methode. The seven compound namely Myrcetin, Kaempferol, Quercetin, Baicalein, Luteolin, Apigenin, and Epicatechin will interact with the SARS-CoV-2-MPro receptor (GDP ID: 7AHA) using the Autodock-Vina program. This study indicates that the original re- validated ligand-receptor RMSD value was 2.3, and the binding energy value was -4.2. The seven compounds have better binding energy values than the original ligands. The best secondary metabolite of Butterfly Flower is Baicalein, with a binding energy of about - 8.5. Blue Butterfly Pea flower compound are promising candidates for food applications that are efficacious as Sars-Cov-2 Main Protease inhibitors due to similar drug properties, safety, and effectiveness as a preventive measure against COVID-19.

Keywords: Covid-19; In silico; Main Protease; Bunga Telang; Blue Butterfly Flower; Clitoria ternatea L.


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