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Abstract

EVALUATION OF HEPATITIS B SURFACE ANTIGEN SECRETION INHIBITION AND HEPATOPROTECTIVITY BY HEP-02, AN HERBAL FORMULATION

Dr. Sweta T Kothari*, Devanshi Gohil, Dr. Zaiba Shaikh, Dr. Milind Patil,Dr. Abhay Chowdhary

Abstract

Hepatitis B virus (HBV) infects around 350 million of the globalpopulation. The current antivirals are laden with side effects as well asexpense burden. An alternative medication based on Ayurveda is beingproposed to counter this scenario. HEP – 02 is a herbal formulationused for the treatment of hepatitis B virus. It is also indicated foralleviation of hepatotoxicity. The molecular mechanism involved inthe anti-HBV activity of this formulation is being studied using in-vitromodels for the first time. Inhibition of Hepatitis B surface antigen(HBsAg) secretion from the transfected human hepatocarcinomaPLC/PRF/5 cells, as well as inhibition of the surface antigen bindingwas taken up in the present study. Suppression of HBsAg productionand inhibition were best observed at 150μg/mL and this concentration was used to determinethe hepatoprotectivity in a Kupffer cell-hepatocyte in-vitro co-culture, determined by theexpression of cytokines TNF-α, IL-6 and IL-10, in presence of bacterial lipopolysaccharide.The results indicate that HEP-02 could thus be beneficial in the treatment of liverinflammation in Hepatitis B.

Keywords: HEP-02, HBsAg secretion, Kupffer cells, LPS, inflammation, hepatoprotectivity.


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