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Abstract

COMPARATIVE EVALUATION OF EFFICACY OF TOPICAL CURCUMIN AND CORTICOSTEROID IN TREATMENT OF OLP

*Dr. Harmi P. Patel, Dr. Shilpa J. Parikh, Dr. Jigna S. Shah

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Abstract

Introduction: Oral Lichen Planus (OLP) is a chronic inflammatory mucocutaneous disease affecting the oral cavity which has been associated with severe burning sensation which in turn affects the quality of life of the patients. Its treatment is often symptomatic ad includes topical and systemic corticosteroids. Although corticosteroid therapy is usually successful, but may induce candidiasis and mucosal atrophy. The chronicity and recalcitrant nature of the disease demand the long term use of these drugs with ensuing adverse effects. Turmeric and its active ingredient, “curcumin”, have been found to have antiinflammatory, antioxidant and anticancer properties. Hence, this study was done to compare the efficacy of topical triamcinolone and curcumin in the management of oral lichen planus. Materials and Methods: A study was conducted on 36 patients diagnosed with OLP divided into two groups, Group 1 (0.1% triamcinolone acetonide) Group 2 (curcumin oral gel). The Subjects in Group I were asked to apply 0.1 % triamcinolone acetonide and in Group II were asked to apply 1% curcumin oral paste three times a day for three months on the lesion. Patients were recalled for the evaluation of progression of the treatment for 3 months. Follow up was done on the 1st week, 2nd week, 4th week, 12th week of treatment period. At follow up visit curative response of two different treatment modalities for OLP lesions were assessed using reduction in VAS scale and Thongprasom score. Results: There was statistically significant reduction in mean VAS score and Thongprasom score (Appearance score) of lesion were seen in both the treatment groups on subsequent follow up. Statistically no significant difference were found between two treatment groups. Conclusion: The results of the present study suggested that local use of curcumin can be effective in improving the symptoms of patients with oral lichen planus without any side effects.

Keywords: Curcumin, Triamcinolone acetonide, Oral Lichen Planus.


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