WJPR Citation New

  All Since 2019
 Citation  7475  4312
 h-index  28  21
 i10-index  197  83

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND EVALUATION OF IN SITU GEL OF LEVOFLOXACIN AND DEXAMETHASONE

Prashant Pachori*, Aditya Tiwari and Nitendra Sahu

.

Abstract

In-situ gel of Levofloxacin and dexamethasone was formulated and evaluated. During the preformulation, the solubility, Melting point, Wavelength of maximum absorption (╬╗max) and Calibration curves were obtained of Levofloxacin and Dexamethasone. Gellan based in situ gel systems were prepared by dissolving gellan alone and its combination with sodium alginate and/or HPMC in hot phosphate buffer mannitol (5% m/V) were added as isotonicity agent. Different evaluations were carried out as visual appearance, transparency, clarity, pH, drug content, viscosity, in-vitro gelation studies, gel strengths, bioadhesion, and sterility, all evaluated parameter are under limit as required for insitu gel formation. Among the all prepared L5 has drug contain above 99% of both drugs gelation immediate and remains for an extended period, Gel Strength (peak Load) of 72g and best bio-adhesion of 35g. %Cumulative drugs release from formulation L5 in STF solutions was studied where 69.72% Levofloxacin and 72.34% Dexamethasone was released. The ophthalmic formulations must be isotonic to avoid damage to delicate tissues of eye. It is concluded that the optimized in-situ gel formulation is a better in results and evaluation parameters.

Keywords: In-situ gel, Levofloxacin, Dexamethasone, Isotonicity, Bioadhesion.


[Full Text Article]  [Download Certificate]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More