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Abstract

FORMULATION AND OPTIMIZATION OF NOVEL EXTENDED RELEASE MUCOADHESIVE BUCCAL PATCHES OF CARVEDILOL

Chanda Bano*, Aditya Tiwari and Nitendra Sahu

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Abstract

The carvedilol characterized as white powder freely soluble in water, 0.1N NaOH, 0.1N HCl, 7.4pH buffer and insoluble in ethyl acetate, having melting point 122 OC and partition coefficient 0.868. UV spectrogram of carvedilol scanned from 200- 400 nm, λmax found at 220nm. Calibration Curve prepared in 7.4pH buffer and water with R2 value 0.996 and 0.999 respective also calculated Linear equation. all the formulated transdermal patches are evaluated and found, all are flexible smooth and translucent, weight variation was under limits, average thickness was 0.15mm found, average tensile strength was 0.9 Kg/cm2 found, drug content was 0.73 mg/cm2 average, moisture content % and moisture uptake % also evaluated. The dissolution study of all formulation shows the percentage drug release were found to be F1-93.10%, F2 -95.25%,F3- 96.16%, F4- 93.95%, F5-96.91% and F6-88.25%, in 24 minutes. According to drug release studied F-3 and F-4 formulations shows excellent drug release profile in steady way. The data of drug release, it was found that all the formulations follow diffusion mechanism for the drug release. Cumulative amount of drug released Q (μg/cm2) at different time intervals and steady state flux (Jss, μg/cm2.hr) were obtained. Also permeability coefficient (Kp) are calculated and found F-3 and F-4 has steady diffusion per unit membrane surface area. Also it was observed that the flux and permeability of Carvedilol.

Keywords: Carvedilol, Transdermal patches, Extended release, Mucoadhesive, Buccal patches.


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