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Abstract

NUCLEIC ACID BASED THERAPEUTIC DELIVERY SYSTEM: A REVIEW

Prachi Thakur, Pranshu Tangri*, Manish Kumar Mishra and Shaffi Khurana Tangri

Abstract

Nucleic acids have not been widely considered as an optimal material for drug delivery. The development of nucleic acid-based therapeutics has garnered tremendous interest in the past two decades as a new category of biologic. Gene therapy using nucleic acids has many clinical applications for the treatment of diseases with a genetic origin as well as for the development of innovative vaccine formulations. Targeted gene therapies have emerged as potential strategies for treatment of such diseases. These therapies depend upon rare-cutting endonucleases to cleave at specific sites in or near disease genes. Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. Among several talented new drug delivery systems, liposomes characterized an advance technology to deliver active molecules to the site of action, and at present, several formulations are in clinical use. This review focuses on the properties of nucleic acid based therapeutics, also focuses on potential target disease for gene therapies, gene therapies, gene expression, liposomal gene delivery system. We discuss recent progress in nucleic acid based drug delivery strategies, their potential, unique use cases, and risks that must be overcome or avoided.

Keywords: Nucleic acid, drug targeting, gene therapy.


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