Abstract

SOLUBILITY ENHANCEMENT TECHNIQUES- A REVIEW ON CONVENTIONAL AND NOVEL APPROACHES

Dhaneshwar Kumar Vishwakarma*, Jai Narayan Mishra, Shriyanshi Tripathi, Pooja Verma and Upasana Pandey

Abstract

Solubility is the method of dissolving solute into the given solvent which gives a homogenous phase in a mixture at specific conditions such as temperature, pH and pressure. Poor solubilisation is the biggest issue during manufacturing of any new chemical moiety. This article aims to elaborate the techniques of solubility enhancement to attain the improved absorption and high bioavailability. The solvent of choice for any liquid parenteral preparation is water. Different techniques are involved in enhancing the solubilisation property of drugs that have solubility issues involves sonocystallisation, use of surfactant, particle size reduction, solid dispersion, salt formation, complexation and cryogenic techniques. The properties that are responsible for selection of solubility enhancing techniques are drug, required dosage form and site of absorption.

Keywords: Bioavailability, Surfactant, Solubility Enhancement, Dissolution, Solid Dispersion, Inclusion Complexes, Bioavailability, Hydrotrophy.