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Abstract

DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION NEW SERIES OF AZETIDINONE BASED PYRIMIDIN-2-ONE DERIVATIVES

Parth P. Patel*, Dharati D. Patel, Piyush J. Vyas and Suresh C. Ameta

Abstract

Heterocyclic Compounds have so far been synthesized mainly due to the wide range of biological activities. Azetidinone plays an important role in biological field. From these reviews we synthesized a new series of 3-chloro-4-(3,4-dimethoxyphenyl)-1-{4-[6-(2-hydroxyphenyl) -2-oxo-1,2,5,6-tetrahydropyrimidin-4-yl]phenyl}azetidin-2-one derived from 3-chloro-4-(3,4-dimethoxyphenyl)-1-{4-[3-(substitutedphenyl) prop-2-enoyl]phenyl}-azetidin -2-one and urea using ethanol as a solvent. The title compounds were characterized by element analysis, and NMR spectral data. All the compounds were tested for their IR antibacterial and antifungal activities by broth dilution method.

Keywords: Azetidinone, IR, NMR, MTCC, broth dilution method.


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