Abstract

CONTROLLED DRUG DELIVERY SYSTEMS: A REVIEW

Rakhi Raikwar*, Aafrin Khan and Yogendra Malviya

Abstract

Controlled release products are designed to maintain constant therapeutic plasma concentration of the drug within the therapeutic range of the drug over prolonged period and offer minimum side effects. This can be achieved using a variety of delivery systems. Oral Sustained release (SR) or Controlled release (CR) products provide an advantage over conventional dosage forms by optimizing biopharmaceutics, pharmacokinetic and pharmacodynamics properties of drugs in such a way that it reduces dosing frequency to an extent that once daily dose is sufficient for therapeutic management through uniform plasma concentration providing maximum utility of drug with reduction in local and systemic side effects and cure or control condition in shortest possible time by smallest quantity of drug to assure greater patient compliance. This review briefly emphasizes about the controlled release drug delivery system characteristics, classification and release mechanisms.

Keywords: control release, sustained release, administration, diffusion, Reservoir, Matrix system, Dissolution Controlled Systems, zero order type.