Abstract

PROSPECTIVE ASSESSMENT OF PRECRIBING PATTERNS OF PROTON PUMP INHIBITORS AT A TERTIARY CARE HOSPITAL, BANGALORE

Gopinatha K.*, Bhanupriya K. R., Bhanupriya K. R., Misba Farheen and Pradeep C.

Abstract

Background: Drug utilization evaluation of proton pump inhibitors (PPI) is essential considering the rational use and associated risks with their therapy. Objectives: The main objective of the study is to evaluate prescribing pattern of Proton pump inhibitor and to evaluate its cost and also to identify and report drug interactions or Adverse drug reaction (ADR). Methodology: A 6-month prospective study was conducted in 202 patients from the department of general medicine of either gender with ≥18 years of age. The data was collected from patient case record, discharge summary and recorded in self designed data collection form. Total and average cost of different generic and route of administration were calculated. Results and discussion: PPIs prescription was higher in males (55.45%) than in females (44.55%). The maximum number of patients were from age group of 41-50 years. Based on NICE guidelines it was found that the prevalence of appropriateness of PPIs prescription was higher. The most commonly prescribed PPI during admission and discharge was pantoprazole (PAN), preferred route of administration during admission and discharge was parenteral and oral respectively. Inj. Pantoprazole had a maximum cost were as Tab. Rabeprazole and Cap. Esomeprazole had minimum cost. Conclusion: PPIs are one of the most often prescribed drugs, hence its long-term use may lead to many adverse reactions. Therefore, it is critical to raise knowledge regarding the proper use of PPI. As a result, proper risk assessment and updating of the PPI indication at discharge should be a top priority.

Keywords: Drug Utilization Evaluation, Proton Pump Inhibitors, Total and Average cost, Adverse Drug Reaction (ADR).