Abstract

A REVIEW ON UTILIZATION OF NATURAL SUPERDISINTEGRANT IN THE ADVANCEMENT OF ORALLY DISPERSIBLE TABLET

Dhanshree R. Tat*, Naresh R. Jaiswal, Gitanjali C. Chavan, Prajakta N. Acharya and Maya M. Sonawane

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Abstract

In recent years, orodispersible tablets as a novel drug delivery system are emerging as an alternative to conventional oral drug delivery systems. Despite being the most accepted route of drug administration conventional oral tablets have a drawback of difficulty in swallowing (dysphagia). This problem can be solved by developing orally dispersible tablets which disintegrate rapidly within a few seconds in saliva in the mouth without the use of water. Thisquick disintegration is due to the action of superdisintegrant in the formulation which leads to rapid absorption, improved bioavailability and better patient compliance. Various synthetic disintegrants such ascrospovidone, croscarmellose sodium, sodium starch glycolate have been used to formulate orally dispersible tablets. But recently researchers are investigating use of natural superdisintegrantsuch as hibiscus rosasinesis, Plantago ovata, Lepidium sativum, Fenugreek and Guar gum over the synthetic superdisintegrants. This is because naturally obtained polymers are more beneficial as they are non-toxic, economical, chemically inert and easily available. Further, they are potentially degradable and compatible with other excipients in the orally dispersible tablet due to their natural origin. Most of the natural disintegrant are capable of chemical modification to design tablets of specific properties such as drug release and desired therapeutic effect. In this review, the main importance is given on different types of natural superdisintegrants used in formulation of oro-dispersible tablet.

Keywords: Natural superdisintegrant, Synthetic superdisintegrant, bioavailability, dysphagia,orally dispersible tablets.