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Abstract

FORMULATION AND EVALUATION OF FLOATING-PULSATILE DRUG DELIVERY SYSTEM OF NIFEDIPINE

Anamika Kol*, Dr. Brajesh Kumar Arjariya, Sheenam Mansuri, Dr. Mohd. Jalaluddin, Rahim Khan and Rahul Dubey

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Abstract

The goal in drug delivery research is to develop formulations that meet therapeutic needs relating to particular pathological conditions. Up to late 1980`s design of drug delivery systems governed by the homeostatic theory. Variations in physiological and pathophysiological functions in time, also need for variations of drug plasma concentration has brought a new approach to the development of drug delivery systems, chronopharmaceutical drug delivery. The human body has many built-in rhythms known as biological clocks. Broadly, these can be classified as Ultradian, Circadian, Infradian and Seasonal. Ultradian cycles are shorter than a day, e.g., time taken for a nerve impulse to be transmitted. To develop and evaluate floating-pulsatile System for a cardiovascular drug, Nifedipine; with a four-five-hour delay in release after oral administration. So that the dose administered at bedtime, drug is released after the initial delay such that maximum plasma level occurs in the early morning hours, when the patient is most at risk. The inner core tablets were prepared by using direct compression method. Different preliminary batches of core tablets were taken in to fix concentration of superdisintegrant in tablet. Total 10 tablet were weighed and powder equivalent to 25 mg of Nifidepine was weighed and dissolved in methanol then filtered through Whatman filter paper. The developed system offers a simple and novel technique for pulse release of drugs. From the results it is concluded that the PRT we prepared could achieve a rapid release after lag time of 4±0.2h with the relatively low variability. The drug release profile of optimized batch K6+F4 was found to be follow korsmeyer and peppas model. So, it is concluded that formulation release the drug by diffusion and erosion method.

Keywords: Nifedipine, Chronopharmaceutics, Chronotherapy, Pulsatile release tablet.


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