Abstract

LIPOSOMES: A NOVEL DRUG DELIVERY SYSTEM TO TREAT OCULAR DISEASES

Abi C. Varghese, Hardeep Kaur, Anshika, Puneet Kaur, Honey Kapoor and Navjot K. Sandhu*

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Abstract

Liposomal drug carriers now provide a wide range of options for ocular delivery. The delivery of medications to ocular tissues is a tough job for formulation experts. Liposomes have several benefits, allowing them to be employed in a wide range of applications. Among other things, they can serve as useful drug carriers in preclinical and clinical trials. Physiological obstacles (nasolacrimal discharge, blink), anatomic obstacles (static and dynamic), enzymatic activity, and metabolism obstacles all obstruct drug transport towards anterior and posterior regions. Liposomes are categorized according to their structure, inventions, Intravitreal Implants, classification, preparation methods, advantages, disadvantages, applications, and formulations. Furthermore, the recent inventions those are related with ocular drug delivery technologies also been elaborated. Manuscript also includes the application of lipid nanoparticles those are used in the treatment of ocular disorders.

Keywords: Liposomes, Ocular drug delivery, lipid nanoparticles, posterior segment, anterior segment, applications.