Abstract

REVIEW ON HEMATOPOITIC STEM CELL TRANSPLANTATION IN RHEUMATIC AUTOIMMUNE DISEASE

Thati Sravani*, Sumaiya Saleem, Indurthi Bharathi, Devagupthapu Kunthitha Devi, Purushothama Reddy K. and Kantamaneni Padmalatha

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Abstract

Stem cells develop in the embryo and produce a variety cells that develop to produce tissues during the organogenesis process. In addition, stem cell is characterized by an ability to indefinitely selfrenew. Stem cells are broadly classified into embryonic stem cells and adult stem cells. Adult stem cells can be genetically reprogrammed to form pluripotent stem cells and exist in an Embryonic like state. Human embryonic stem cells exist only briefly during the early stages of development. Adult stem cells are found all over the body and help to regenerate tissues after apoptosis or tissue repair. Adult stem cells called hematopoietic stem cells (HSC) produce blood and immune cells. Autoimmune responses are sustained due to the perennial persistence of tissue self-auto reactive lymphocytes. Immune reset is a process that results in the production of new self-tolerant cells after chemotherapy-induced lymphocyte destruction. Autologous HSC transplantation is based on this (HSCT). Because of complaints related transplant-related mortality and morbidity, HSCT was initially limited to refractory autoimmune rheumatic disorders (AIRD). However, with a better understanding of patient selection, conditioning, and supportive care, HSCT for AIRD has come a long way.

Keywords: Hematopoietic stem cell, Transplant related mortatlity, HSCT in autoimmune rheumatic disease, Stem cell therapy.