Abstract

IMPACT OF PROCESSING VARIABLES ON THE PREPARATION OF EUDRAJIT L100 & EUDRAGIT RSPO LOADED ACYCLOVIR MICROBEADS BY IONOTROPIC GELATION METHOD

Paramita Dey*, Sangita Panja and Bratati Bandyopadhyay

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Abstract

The purpose of the research was to develop sustained release microbeads of acyclovir using Eudragit RSPO, EudragitL100 and sodium alginate as polymers following ionotropic gelation technique. Calcium chloride and gluteraldehyde were used as the ionotropic gelling agent. Sodium alginate was crosslinked by calcium chloride leading to a slower release of the drug. The percentage yield of all the formulations (F1-F5) was found to be within the range of 92.85% to 98.36% which denotes the suitability of the method of formulation and the average particle size was found to be within the range of 1096- 1389 μm. The processing variables affected the properties of the microbeads in different ways amongst which the F2 formulation shows high entrapment efficiency, low swelling ratio followed a sustained release profile of the drug. No interaction was found between polymer drug which can be proved by FTIR and DSC analysis.

Keywords: Acyclovir, Eudragit RSPO, EudragitL100, Microbeads, Ionotropic gelation technique.