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Abstract

THE COMPARISON OF IN-VITRO ANTI-INFLAMMATORY ACTIVITY OF ABELMOSCHUS ESCULENTUS & CAMELLIA SINENSIS

Reshma Vishal Pawar*, Radhika Mane, Pansare Shubhangi, Patil Laxmi, Nanavare Rutuja and Mhasawade Shubhangi

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Abstract

Ethyl acetate extract of Abelmoschus esculentus & Camellia sinensis was assessed for its anti-inflammatory activity by invitro methods. Invitro anti-inflammatory activity was evaluated using membrane stabilization, and Protein denaturation activity at different concentrations. Diclofenac sodium (100 μg/ml) were used as standard drugs. The results showed that both the plants have significant antiinflammatory activity, but EAECS have more activity than EAEAE. In the heat induced protein denaturation EAECS showed % inhibition 68.42% at concentration 500 μg/ml. Which is close to % inhibition of standard i.e. 65.78% at concentration of 100 μg/ml. and EAEAE showed % inhibition 55.26 % at concentration 500 μg/ml which is near about % inhibition by EAECS at concentration of 400 μg/ml. In the heat induced hemolysis of erythrocyte, EAECS showed % inhibition 69.52% at concentration 500 μg/ml. Which is near about % inhibition of standard i.e. 70.47% at concentration of 100 μg/ml and EAEAE showed % inhibition 58.09% at concentration 500 μg/ml which is near about % inhibition by EAECS at concentration of 400 μg/ml. In the hypotonicity induced haemolysis of erythrocyte, EAECS showed % inhibition 67.56% at concentration 500 μg/ml which is more than % inhibition of standard i.e. 54.05% at concentration of 100 μg/ml. hence present study conclude that EAECS have more potent constituents responsible for anti-inflammatory activity than that of EAEAE.

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