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Abstract

SIMULTANEOUS ESTIMATION OF SITAGLIPTIN PHOSPHATE AND METFORMIN HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM BY FTIR SPECTROPHOTOMETRIC

Pragati Sinha*, Mukul Maurya and Manoj Kumar Mishra

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Abstract

Simple, accurate and precise FTIR methods have been developed for the determination of Sitagliptin phosphate monohydrate (STG) and metformin HCL (MET). The simultaneous estimation was carried out at detection wavelength of 206nm using variable wavelength detector. Metformin hydrochloride and Sitagliptin phosphate is an ant diabetic drug. The FTIR spectra of the compound have been recorded. The light absorption activity in the UV-vis region of the drug under different storage conditions has also been analyzed. The characteristic of the drug have been identified and assigned using FTIR spectrum. The proposed methods used to determine each drug in binary mixture with metformin and ternary mixture with metformin and Sitagliptin alkaline degradation product that is obtained after alkaline hydrolysis of Sitagliptin. The methods developed were satisfactorily applied to the analysis of the pharmaceutical formulations and proved to be specific and accurate for the quality control of the cited drugs in pharmaceutical dosage forms.

Keywords: FTIR, UV-Visible spectra, Metformin hydrochloride, Sitagliptin phosphate, Pharmaceutical preparation.


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