Abstract

DESIGN, FORMULATION AND EVALUATION OF GASTRO RETENTIVE FLOATING TABLETS OF NATEGLINIDE

Abhishek Yadav*, Pranav Kumar Upadhyay and Rajeev Shukla

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Abstract

The global presence of diabetes has been rising day by day and it accounts for endangering 6.6% of the total population of the world. The increase in the blood glucose levels is the basic criterion of describing diabetes. It is also symptomized by glycosuria, hyper lipidaemia, ketonemia, etc. Insulin and oral hypoglycaemics are the two most widely used categories of drugs utilized for treatment of diabetes. Oral hypoglycaemics is the class of drugs associated with lowering the glucose levels, but many of them suffer from the drawback of smaller half lives, short residence time. The gastroretentive dosage forms help in overcoming these drawbacks and also increase the bioavailability of the drug administered. The gastroretentive dosage form has shown a better potential keeping in mind the research aspect as well as the commercial aspect of the formulation. Gastroretentive formulations consisting of oral hypoglycaemics have found a vast market and have been formulated and marketed by various MNCs. The present article tries to describe all the recent advances made and the current market status of the aforesaid technology.

Keywords: Gastroretentive, Hypoglycemics, Nateglinide, Glinate, Bio polymer chitosan.