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Abstract

FORMULATION AND EVALUATION OF FLOATING TABLET OF RAMIPRIL

Prachi Srivastava*, Prof. Dr. Pranav Kumar Upadhyay and Dr. Rajeev Shukla

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Abstract

The real challenge in the development of a controlled drug delivery system is not just to sustain the drug release but also to prolong the presence of the dosage form in the stomach or the upper small intestine until all the drug is completely released in the desired period of time. The residence of a drug delivery system in the upper part of the gastrointestinal tract (GIT) can be accomplished by several drug delivery systems, such as swelling, intragastric floating systems and expandable systems, Bioadhesive systems, high density systems, modified shape systems, delayed gastric emptying systems, and low density super porous systems, FDDS, also called hydrodynamically balanced system. It is an effective technology to prolong the gastric residence time in order to improve the bioavailability of the drug. This technology is suitable for drugs with an absorption window in the stomach or in the upper part of the small intestine, the drugs acting locally in the stomach and for drugs that are poorly soluble or unstable in the intestinal fluid. FDDS have a bulk density lower that gastric fluid and thus remains buoyant in stomach for prolonged period of time without affecting gastric emptying time. The drug is released slowly, while the system is floating on the gastric contents. They are also known as hydro dynamically balanced systems (HBS) as they are able to maintain their low density, Based on mechanisms of floating, two different technologies. Effervescent FDDS Non-effervescent FDDS.

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