Abstract

NOVEL DRUG DELIVERY SYSTEM - NIOSOMES

Sumitra Nareshkumar Sutar* and Y. N. Gavhane

Abstract

There has been a major revolution in the creation of novel drug delivery systems in recent decades, and numerous research publications have been published in scientific journals describing the potential of niosomes to serve as a carrier for the delivery of various medications. Niosomes are microscopic vesicles generated by nonionic surfactant self-assembly. Niosomes, which are generated by selfassociation of nonionic surfactants and cholesterol in an aqueous phase, are attractive drug carriers because of their biodegradable, biocompatible, nonimmunogenic structure, chemical stability, low manufacturing cost, easy storage and handling, and low toxicity. The vesicular system of niosomes, with its bilayer structure constructed by nonionic surfactants, can increase a drug's bioavailability to a predetermined area for a period of time. They can protect drug from harsh environment and also prolongs the drug release. This review article gives a basic idea about niosomes along with its advantages, disadvantages, factors affecting, formulation, methods, evaluation, and applications.

Keywords: Niosomes, Formulation, Preparation, Characterization, Application.