Abstract

DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF ATORVASTATIN CALCIUM

Dharani Priya B.*, Dr. Padmapreetha J., Indrapriyadharshini C., Praveen Kumar C.

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Abstract

Background: Atorvastatin calcium could be a 3-hydroxy-3-methyl glutyryl coenzyme A (HMG CoA) reductase inhibitor is a statin with well-known lipid lowering effects. The oral bioavailability of atorvastatin calcium is 14% due to incomplete intestinal absorption or gut wall extraction. Floating drug delivery systems are the gastro retentive forms that precisely control the discharge rate. This can be achieved by use of assorted polymeric substances including natural polymers. These polymers are inexpensive, safe and available in an exceedingly form of structures with versatile characteristics. Objective: The aim of the study was to enhance oral bioavailability of atorvastatin calcium in gastro retentive floating dosage form by using natural and artificial gums. Methods: Gastro retentive floating tablets of atorvastatin calcium were formulated by wet granulation method using altered concentrations of HPMC K15, Tamarind gum and Sterculia gum as polymers. The prepared tablets of atorvastatin calcium were evaluated for precompression and post compressions parameters. Results: The varying concentration of polymers were found to effect on in-vitro drug release rate. Atorvastatin calcium gastroretentive floating tablets were shown that the formulation F9 was found to be the best formulation as it releases 87.66 % atorvastatin calcium in a very controlled manner for an extended period of your time (up to 8 h). The discharge data was fitted to numerous- mathematical models like higuchi, Korsmeyer-Peppas, first order and zero order to gauge the kinetics and mechanism of the drug release. Conclusion: From the study it had been concluded that Gastroretentive effervescent floating tablet formulation F9 (1: 7 ratio) of Atorvastatin calcium using Sterculia gum as natural polymer by wet granulation technique.

Keywords: Atorvastatin calcium, Gastro retentive, Floating tablet, Total floating time.