WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF SELECTED HERBAL MEDICINE

Abdur Rab*, Archana Singh and Nitendra Sahu

Abstract

The major active constituents are present in ethanolic extract in Solanum xanthocarpum and methanolic extract in A. officinarum rhizome. The developed herbal gel was greenish in color, translucent in appearance and showed good homogeneity with absence of lumps. Formulation F6 had good values of spreadability, viscosity, pH, drug content and during the accelerated stability studies the appearance was clear and no significant variation in spreadability, pH and drug content was observed. Four different concentration of extract 1mg/ml, 2 mg/ml, 4 mg/ml and 6 mg/ml were used for each plant extract. Among which ethanolic extract of S. xanthocarpum at concentration 6 mg/ml showed 50.1% protection of HRBC in hypotonic solution and A. officinarum extract at concentration 6 mg/ml showed 56.89 while combination of extract (1:1 ratio) at concentration 6 mg/ml showed 67.89% protection of HRBC in hypotonic solution. Percentage inhibition of edema by hydroalcohalic gel FH containing S. xanthocarpum and A. officinarum extracts containing was observed to be- 23.19% (at 1 hr.) and 46.23% (at 4 hr.). All the results were compared with standard voveran gel. The result revealed that formulations formulation FH containing both plants extract has potent anti-inflammatory action % Inhibition (Mean + SEM). Hydroalcoholic Gel formulation containing both plant extract FH and marketed products did not cause any skin reaction. It can be assured that both plants extract and the excipients did not cause any skin irritation and can be used in the gel formulation.

Keywords: Solanum xanthocarpum, Alpenia officinarum, rhizome, hydroalcohalic gel.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More