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Abstract

REVIEW EVALUATION OF MOUTH DISSOLVING FILMS: PHYSICAL AND CHEMICAL METHODS

Hemraj L. Pawar* and R. T. Mogal

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Abstract

Orodispersible is the term referred to dosage form which disperse or disintegrate into mouth i.e. oral cavity. The time required to disintegrate should be not more than 3 minutes. Dosage forms in which they are available are tablets and mouth dissolving films which when placed in oral cavity release drug instantaneously with rapid onset of action. An ideal ODF should exhibit adequate flexibility, elasticity, softness, resist the breakage, minimum disintegration time and taste compliance. All these parameters need to be evaluated during the formulation development stage and required standard protocols. The greatest challenge is to develop a high quality film which also necessitates constant evaluation and understanding the performance of the do sage form, the critical steps to achieve a successful product development. Despite the intense focus on film based drug delivery system, there are no official standardized methods for its evaluation. Significant efforts have been made to demonstrate and improve the efficacy, potency and safety of film using in vitro and in vivo assessments.

Keywords: Orodispersible films (ODF), Oral delivery, Tensile strength, Evaluation.


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