Abstract

ONE POT SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF METHYL- 6-METHYL-4-PHENYL- 2-THIOXO-1, 2, 3, 4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE

B. V. Durgarao, Suresh Gowd, Banoth Reddy, Dr. N. Srinivasa Rao and Dr. N. Krishna Rao*

Abstract

The present work deals with the exploration of chemistry and medicinal diversity of pyrimidine-2-thiones. An efficient three component one pot synthesis of Methyl-6-methyl-4-phenyl -2-thioxo- 1, 2, 3, 4-tetrahydro pyrimidineidin-5-yl)ethanone based on the reaction of readily available substituted aryl aldehyde, active methyl group of compound and thiourea, followed by camphor sulphonic acid as catalysed cyclocondensation. The desired products are prepared in excellent yield under mild, solvent less condition. The structure of the desired products has been analysed by their advanced spectroscopic data 1HNMR, 13CNMR and LCMS spectral data and also structural determination was calculated by elemental analysis. In addition to examined the biological activity.

Keywords: Substituted aryl aldehyde, acetylacetonate, thiourea, camphorsulfonicacid, cyclocondensation antimicrobial activity.