Abstract

STEM CELLS: A PROMISING THERAPEUTIC METHOD AND IT’S REGULATION BY MICRO- RNAs

Priya Pandey, Dolly Nirwan, Preeti Rani, Dhiraj Kumar* and Nitin Kumar

Abstract

Stem cells (SC) are specialized cells that are suitable to develop into different cell types. Stem cell remedy is also known as regenerative drug as it promotes the form response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. These have capacity to make any new tissue in the human body, hence have great eventuality for future therapeutic uses in tissue regeneration and repair. Niches are local tissue micro environments that maintain and regulate stem cells. Micro RNAs (miRNAs) are a class of short non-coding RNAs, whose importance is increasingly nowadays. This review is a preface to the world of stem cells and discussion about various definition, classification as well as its role in treatment of various disease. It also focuses on role of miRNAs in the regulation the cell cycle. Presently, regenerative drug is a major focus of exploration not only to find curatives but also to understand introductory biology and the pathogenesis of disease. Although a number of ethical issues have arisen in stem cell exploration, recent advances in stem cell isolation and development have helped scientists to identify and culture specific cell types for regeneration of tissue in various disorders such as wound healing, kidney morphogenesis, lung morphogenesis, diabetes and other organs.

Keywords: Stem cell, wound healing, kidney - lung morphogenesis, diabetes, cell cycle, miRNAs biogenes.