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Abstract

H2 HISTAMINERGIC RECEPTOR MEDIATED COMPLICATIONS AND LIGANDS FOR THERAPEUTIC PURPOSE

Sumit Kumar* and Ganesh N. Sharma

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Abstract

Histamine endeavours its pharmacological and physiological effects by come in contact with at least two distinct receptors. Histamine has a major function in allergic reactions. H2 receptor plays a key role in gastric secretion regulation by inducing acid and peptin secretion. The function, structure, distribution, and affinity for histamine are all characteristics of histamine receptors. GI diseases are most common problems in tropical countries and commonly manifest as functional dyspepsia, GERD, Dysbiosis and peptic ulcer diseases etc. H2 receptor antagonists are well tolerated by the general population, and a large percentage of the population uses them to treat these diseases and other minor upper GI symptoms and these are a type of medication which are acid-suppressing and used to get relief from various types of GI problems. Oral administration of H2 receptor antagonists results in good absorption, and all H2 receptor antagonists are available as tablets for oral administration. This review article includes the therapeutic use of H2 Receptor antagonists in the various GI problems.

Keywords: H2 receptor, functional dyspepsia, GERD, peptic ulcer disease, dysbiosis.


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