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Abstract

CLEANING VALIDATION OF TABLET COMPRESSION MACHINE BY SWAB SAMPLING

Poonam D. Khalate*, Pratiksha S. Londhe, Bharatee P. Chaudhari, Vivekkumar K. Redasani

Abstract

Validation of cleaning technique using swab sampling and application in determining residual L-ascorbic acid in production area equipment, as well as confirmation of cleaning procedure efficiency. After producing L-ascorbic acid 10 mg chewable tablets, the swab sampling and UV method for residual determination of in L-ascorbic acid swab samples from equipment surfaces were established and verified. For LAscorbic Acid in tablet form, a unique, safe, and sensitive method of spectrophotometric measurement in the UV region has been devised. Water as diluents were used to develop and validate the technique for L- Ascorbic Acid.

Keywords: Cleaning Validation, Linearity, Swab, Absorbance, UV Spectroscopy, L- Ascorbic Acid.


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