Abstract

FORMULATION AND EVALUATION OF NON- EFFERVESCENT CIPROFLOXACIN FLOATING TABLETS BASED ON EURYALE FEROX SEEDS

Angilicam Avinash*, Mahaboob Sameera Shajahan, Jonna Supriya, Mikkina Venkata Thanusha, Mylari Reshma, Musturi Mallikarjuna and Dr. Kudipudi Harinadha Baba

Abstract

Floating drug delivery system overcomes the physiological problems of gastric retention by decreasing fluctuations in blood drug concentration with consequent reduction in undesirable toxicity and poor efficiency. Ciprofloxacin is a broadspectrum antibiotic active against both Gram-positive and Gram-negative bacteria. It is absorbed completely (70%) after oral administration and having a biological half-life of 3.5 to 4.5 hrs. The purpose of the study was to prolong the gastric residence time of Ciprofloxacin by designing as floating tablets and to study the influence of different polymers on its release rate. Nine formulations of Ciprofloxacin containing varying concentrations of polymers (HPMC E15 and HPMC K4M) were designed. The floating matrix tablets of Ciprofloxacin were prepared by direct compression method. The powder blend was evaluated for angle of repose, bulk density, tapped density, bulkiness, compressibility index and Hausner’s ratio; all these values are within the specified limit which indicates good flow properties. The prepared tablets were evaluated for physicochemical parameters such as weight variation, hardness, friability, floating properties (floating lag time, floating time) and drug content. Invitro release studies revealed that out of 9 formulations, formulation F6 was found to be optimized which showed the sustained drug release of 99.93% for 12 hours. FT-IR spectra revealed that there was no interaction between the drug and the polymer used for floating tablet formulation.

Keywords: Bioavailability, Ciprofloxacin, Floating drug delivery system, Gastric residence time, Sustained release.