FORMULATION AND EVALUATION OF NON- EFFERVESCENT CIPROFLOXACIN FLOATING TABLETS BASED ON EURYALE FEROX SEEDS
Angilicam Avinash*, Mahaboob Sameera Shajahan, Jonna Supriya, Mikkina Venkata Thanusha, Mylari Reshma, Musturi Mallikarjuna and Dr. Kudipudi Harinadha Baba
Abstract
Floating drug delivery system overcomes the physiological problems
of gastric retention by decreasing fluctuations in blood drug
concentration with consequent reduction in undesirable toxicity and
poor efficiency. Ciprofloxacin is a broadspectrum antibiotic active
against both Gram-positive and Gram-negative bacteria. It is absorbed
completely (70%) after oral administration and having a biological
half-life of 3.5 to 4.5 hrs. The purpose of the study was to prolong the
gastric residence time of Ciprofloxacin by designing as floating tablets
and to study the influence of different polymers on its release rate.
Nine formulations of Ciprofloxacin containing varying concentrations
of polymers (HPMC E15 and HPMC K4M) were designed. The
floating matrix tablets of Ciprofloxacin were prepared by direct compression method. The
powder blend was evaluated for angle of repose, bulk density, tapped density, bulkiness,
compressibility index and Hausner’s ratio; all these values are within the specified limit
which indicates good flow properties. The prepared tablets were evaluated for
physicochemical parameters such as weight variation, hardness, friability, floating properties
(floating lag time, floating time) and drug content. Invitro release studies revealed that out of
9 formulations, formulation F6 was found to be optimized which showed the sustained drug release of 99.93% for 12 hours. FT-IR spectra revealed that there was no interaction between the drug and the polymer used for floating tablet formulation.
Keywords: Bioavailability, Ciprofloxacin, Floating drug delivery system, Gastric residence time, Sustained release.
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