FORMULATION AND EVALUATION OF LABETALOL HCL FAST DISSOLVING TABLET BY USING FENUGREEK SEED MUCILAGE
Simpi Sharma*, Vivek Kumar Patel and Prof. Rajeev Shukla
Abstract
Aim: The goal of the present work was to formulation and evaluation
of fast dissolving tablet of Labetalol HCl by using fenugreek seed
mucilage in combination with different superdisntegrants (like: sodium
starch glycolate, Crosspovidine, & Crosscarmellose sodium).
Objectives: The present work basically focused on to enhance the
disintegration of dosage form (to decrease the disintegration time and
to achieved rapid onset on action) by using fenugreek seed mucilage
that increased the rapid disintegration of tablet with different
superdisintegrants and also improved the % cumulative drug release
within 30second. Materials and method: Mucilage were extracted by
using ethyl alcohol (95&%) from fenugreek seed. These isolated
mucilage were evaluated for abundant physicochemical properties
(like: pH, gelatinization temperature, viscosity swelling index, water
absorption index, total microbial load & solubility). FTDs were formulated by using
Labetalol HCl, fenugreek seed mucilage, different superdisntegrants(like SSG, CP,CCS)in
various concentration by direct compression method. Pre- compression parameters and Postcompression
studies (were detected to be within limits. The best formulation F8 had been
showed good post compression parameters result in comparition to the other formulation.
Accelerated stability study were divulge that all prepared FDTs were stable. Conclusions:
Thus, the tablet were prepared by using fenugreek seed mucilage revealed the
superdisintegrants properties.
Keywords: Labetalol HCl, fenugreek seed mucilage, FDTs, superdisintegrants, disintegration time.
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