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Abstract

FORMULATION AND EVALUATION OF LABETALOL HCL FAST DISSOLVING TABLET BY USING FENUGREEK SEED MUCILAGE

Simpi Sharma*, Vivek Kumar Patel and Prof. Rajeev Shukla

Abstract

Aim: The goal of the present work was to formulation and evaluation of fast dissolving tablet of Labetalol HCl by using fenugreek seed mucilage in combination with different superdisntegrants (like: sodium starch glycolate, Crosspovidine, & Crosscarmellose sodium). Objectives: The present work basically focused on to enhance the disintegration of dosage form (to decrease the disintegration time and to achieved rapid onset on action) by using fenugreek seed mucilage that increased the rapid disintegration of tablet with different superdisintegrants and also improved the % cumulative drug release within 30second. Materials and method: Mucilage were extracted by using ethyl alcohol (95&%) from fenugreek seed. These isolated mucilage were evaluated for abundant physicochemical properties (like: pH, gelatinization temperature, viscosity swelling index, water absorption index, total microbial load & solubility). FTDs were formulated by using Labetalol HCl, fenugreek seed mucilage, different superdisntegrants(like SSG, CP,CCS)in various concentration by direct compression method. Pre- compression parameters and Postcompression studies (were detected to be within limits. The best formulation F8 had been showed good post compression parameters result in comparition to the other formulation. Accelerated stability study were divulge that all prepared FDTs were stable. Conclusions: Thus, the tablet were prepared by using fenugreek seed mucilage revealed the superdisintegrants properties.

Keywords: Labetalol HCl, fenugreek seed mucilage, FDTs, superdisintegrants, disintegration time.


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