Abstract

ROOM TEMPERATURE, METHANE SULFONIC ACID CATALYZED PROTOCOL FOR BENZIMIDAZOLE, BENZOXAZOLE AND BENZOTHIAZOLE SYNTHESIS

Sushil R. Mathapati*

Abstract

In the present research work, we have described synthesis of a series of benzimidazoles, benzoxazoles and benzothiazoles through the cyclisation of 1, 2-phenylenediamine, 2-aminothiophenol, or 2- aminophenol with aryl and heteroaryl aldehydes. The reported protocol is very much efficient in attendance of 5 mol % methane sulfonic acid as a catalyst in 10 mL CH3CN solvent at room temperature. Use of non-corrosive, non-toxic and efficient catalyst at room temperature is the key advantage of reported method and it comes with certain compensations like shorter reaction time, simple work-up technique, high yields and easy availability.

Keywords: Methane sulfonic acid; Cyclization; Room temperature; Benzimidazoles; Benzoxazoles; Benzothiazoles.