Abstract

NAPROXEN: A CHALLENGING APPROACH FOR SOLIDLIPID NANOPARTICLES, DOSAGE FORM, DESIGN, DEVELOPMENT AND EVALUATION OF BCS-II DRUGS

Adarsh Kumar Singh* and Prof. Dr. Pranav Kumar Upadhyay

Abstract

Nanoparticle is the simplest form of structures with sizes in the nm range. In principle any collection of atoms bonded together with a structural radius of < 100 nm can be considered a nanoparticle. In the present time nanoparticle are widely used in many dosage forms due to their good solubility, less size and better penetrability. Nanoparticle can be prepared by using the various methods such as Emulsion- Solvent Evaporation Method, Double Emulsion and Evaporation Method, Salting out Method, Emulsions Diffusion Method, Solvent Displacement/Precipitation method, Polymerization method and Coacervation or ionic gelation method. Applications of nanoparticle in micro wiring are cell specific, internalization, vaccine delivery and gene delivery. Nanoparticles are used in the field of medicines also for the treatment of cancer or for the orthopaedic implants. Nanoparticles show high solubility and fast penetration that’s why they are used in almost formulation now a day.

Keywords: Gold Nanoparticle (AuNPs), Magnetic Resonance Imaging (MRI), Polyvinylpyrrolidone (PVP), Blood brain barrier (BBB).