FORMULATION AN EVALUATION OF CONTROLLED POROSITY OSMOTIC TABLET OF LOSARTAN POTASSIUM
Pallavi Sonkar*, Vivek Kumar Patel and Dr. Rajiv Shukhla
.
Abstract
The aim of present work was to formulate and evaluate controlled
porosity osmotic pump tablets of losartan potassium to prolong the
release of drug of oral administration. Losartan Potassium is an antihypertensive
drug and it acts as an angiotensin II receptor antagonist.
The core tablets were prepared by direct compression technique using
osmogens with varying concentration using HPMC K15M as polymeric
material. The tablet were coated with CA (Cellulose acetate) upon
contact with water it results in situ formation of a microporous
structure. Total nine formulations (F1-F9) were formulated and
evaluated for various parameters such as compatibility studies, drug
content. Weight variation, hardness, thickness, friability, in vitro release studies and
acceralated studies. The drug –excipients interaction were also studied by conducting FT-IR.
After analysis of different evaluation parameters and drug release formulation code F9
showed a promising formulation for drug delivery of Losartan Potassium as a Controlled
porosity osmotic pump tablet with 92.25% drug release for 12hrs. The stability studies were
carried out at 40oC/75%RH for 90 days. There was no significant change in the physical
property during the study period.
Keywords: Losartan Potassium, Controlled Porosity Osmotic pump tablets, Antihypertensive, Microporous structure, Vitro –drug release, Stability studies.
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