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Abstract

FORMULATION AN EVALUATION OF CONTROLLED POROSITY OSMOTIC TABLET OF LOSARTAN POTASSIUM

Pallavi Sonkar*, Vivek Kumar Patel and Dr. Rajiv Shukhla

Abstract

The aim of present work was to formulate and evaluate controlled porosity osmotic pump tablets of losartan potassium to prolong the release of drug of oral administration. Losartan Potassium is an antihypertensive drug and it acts as an angiotensin II receptor antagonist. The core tablets were prepared by direct compression technique using osmogens with varying concentration using HPMC K15M as polymeric material. The tablet were coated with CA (Cellulose acetate) upon contact with water it results in situ formation of a microporous structure. Total nine formulations (F1-F9) were formulated and evaluated for various parameters such as compatibility studies, drug content. Weight variation, hardness, thickness, friability, in vitro release studies and acceralated studies. The drug –excipients interaction were also studied by conducting FT-IR. After analysis of different evaluation parameters and drug release formulation code F9 showed a promising formulation for drug delivery of Losartan Potassium as a Controlled porosity osmotic pump tablet with 92.25% drug release for 12hrs. The stability studies were carried out at 40oC/75%RH for 90 days. There was no significant change in the physical property during the study period.

Keywords: Losartan Potassium, Controlled Porosity Osmotic pump tablets, Antihypertensive, Microporous structure, Vitro –drug release, Stability studies.


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