Abstract

IDENTIFICATION OF POTENTIAL DRUG-DRUG INTERACTIONS IN CARDIOLOGY DEPARTMENT IN A TERTIARY CARE HOSPITAL

Riya Sara Reji*, Aqueena George, Niketha Vikraman, Ann Mariya Augustine, Lekshmi Gayathri and Praveen Kumar

Abstract

Background: DDI can be defined as interaction between two or more drugs, resulting in either synergistic or antagonistic or idiosynergestic effect of the drugs. A DDIs is a major concern in patients with CVD due to multiple co-existing conditions and because of the wide class of drugs they receive. Other risk factors such as age, polypharmacy, pharmacokinetics and pharmacodynamics profile of drugs also alters the overall therapeutic response which results in increased hospital stay and health care cost. Objective: (1) To identify the PDDIs in the Department of Cardiology in a Tertiary care hospital. (2) To assess the data collected and describe the drugs, drug combinations and severity associated with these interactions. Method: The proposed prospective study was conducted over 150 patients of Cardiology department in Aster CMI hospital, Bangalore using the Lexicomp Interct ® app for duration of 6 months. Result: A total of 150 patients were included in the study. 503 interactions were identified among 142 patients. The incidence of pDDIs was 94.6%.The most common pDDIs were between Heparin & Ticagrelor (10.33%), Aspirin& Heparin (9.14%) and Atorvastatin & Ticagrelor (7.95%). Majority of interactions were of moderate severity and of risk classification C which required therapy monitoring. Conclusion: The data was collected to identify the pDDIs. The present study identifies the need for screening prescriptions of cardiovascular patients for pDDIs, monitoring of these patients and usage of Online DDI database to prevent these interactions.

Keywords: ADR-Adverse drug reactions, PDDI-Potential drug drug interactions, CVD-Cardiovascular disease.