Abstract

DEFENCE POTENTIAL OF SOLANUM SURATTENSE AND SENNA ALEXANDRINA AGAINST UROLITHIASIS - AN IN VITRO APPRAOCH

Christynal Oliviya R.* and Dayana Devi A.

Abstract

Urolithiasis or kidney stone formation is an intricate disease that endures the public health around the world. It is a complex process that results from series of several physicochemical events including supersaturation, nucleation, growth aggregation and retention within the kidneys (Mitra et al., 1998). Modern medicines are causing side effects like Extracorporeal Shock Wave Lithotripsy (ESWL) found in drug treatment this may lead to renal injury, decrease in renal function and increase in stone formation. Herbal and Ayurvedic medicine make use of many plant-derived compounds as the basis for evidence-based pharmaceutical drugs and extracted from various medicinal plants improved health and quality of people’s life (Mosihuzzaman 2012). The use of herbal formulations now-a-days is increasing rapidly and to make an antiurolithiatic herbal formulation with a reduced dosage and enhanced onset of action. Certain medicinal plants will be used to treat such kind of disease called urolithiasis especially Solanum surattense (Parmar et al., 2010) and Senna alexandrina (Agarwal and Bajpai, et al., 2010) are used to minimise the chance of formation of kidney stone. Hence, the present study focuses on their efficacy in the treatment of urolithiasis. An in - vitro study of anti-urolithiatic activities of both the plants were carried out by turbidity method (nucleation assay, aggregation assay and growth assay) and calcium oxalate dissolution method (Titration method). The study reveals that both Solanum surattense and Senna alexandrina were having potential antiurolithiatic activity. But when compare the effectiveness of anti-oxidant antiurolithiatic activities S. alexandrina shows significant effect than the S. surattense. So the study suggests that of S. alexandrina plant can be used as drug for the treatment of urinary disease without the side effects.

Keywords: Calcium oxalate; Solanum surattense; Senna alexandrina, Nucleation; Aggregation.