Abstract

ANALYTICAL METHOD DEVELOPMENT TECHNIQUES OF REMDESIVIR: A REVIEW

Subham Kumar Vishwakarma*, Srashti Pal Singh Dabar and Harish Tiwari

Abstract

Remdesivir is a broad-spectrum antiviral single stereoisomer monophosphora- midate prodrug of a nucleoside analogue used to treat severe novel coronavirus disease (COVID-19) caused by SARS coronavirus 2 (CoV-2) infection. Remdesivir is considered as the first medical treatment that the US Food and Drug Administration (FDA) has approved for use in clinical care for COVID-19 patients who are hospitalized. 2-ethylbutyl (2S)-2-[[[(2R,3S,4R,5R)-5-(4- aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan- 2-yl]methoxy-phenoxy phosphoryl]amino]propanoate is the IUPAC name of Remdesivir. In this work, a quick overview of the analytical methodologies developed to estimate this substance is reviewed.

Keywords: Covid-19, Antiviral, Remdesivir, analytical technique, spectroscopy, HPLC.