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Abstract

FORMULATION AND DEVELOPMENT OF TRANSDERMAL PATCHES OF IBUPROFEN WITH NOVEL PENETRATION ENHANCERS

Priti Prabhakar Deshmukh*, Vaibhav Changediya and Vikas Rajurkar

Abstract

When used orally, the non-steroidal anti-inflammatory medication ibuprofen causes stomach discomfort. To avoid this adverse effect, ibuprofen transdermal patches have been developed and evaluated. In this study, polyvinyl pyrrolidone (PVP) polymer basis was used to create Ibuprofen transdermal patches. As a penetration enhancer, four formulations with varying menthol concentrations were created. Menthol weight ratios to PVP ranged from 0% (F0), 5% (F1), 10% (F2), to 15%. (F3). Ibuprofen transdermal patches are assessed for their organoleptic properties as well as their weight homogeneity, thickness, drug content, and in vitro drug diffusion. These assessments revealed that every recipe had positive outcomes. After 180 minutes of in vitro diffusion, 1.7083 mg/cm2 of ibuprofen had diffused using Franz diffusion cells in phosphate buffer pH 7.4 medium. Due to substantial study into transdermal drug delivery, topical formulation has gained popularity during the past ten years. The range of therapeutic substances that can be administered to systemic circulation through the skin is therefore being expanded to include an increasing number of medications. Creams, ointments, gels, patches, and other commonly accessible dose forms for topical treatment are available. Due to the stratum corneum's barrier characteristic, the therapeutic advantages of the aforementioned topical formulations are quite modest (SC). Chemical penetration enhancers (CPEs) are a tried-and-true method for overcoming SC's barrier feature. Many classes of new compounds have been tested for their ability to increase penetration, including SEPA (soft enhancement for percutaneous absorption), for instance.

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